Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy
نویسندگان
چکیده
منابع مشابه
Structural Comparison of Oligoribonucleotides and Their 2 ’ - Deoxy - 2 ’ - fluoro Analogs by Heteronuclear NMR spectroscopy
1 -(2’-Deoxy-2’-fluororibofuranosyl)pyrimidines were synthesized and incorporated into an RNA oligonucleotide to give ~-r[~G~(U,U,(;G)G~GJ-3‘ (Cf: short form of Cdl.f2. = 2’-deoxy-2‘-fluorocytidine; U,: short form of U,,.,,. = 2’-deoxy-2’-fluorouridine). The oligomer was investigated by means of UV, CD, and NMR spectroscopy to address the question of how F-labels can substitute ”C-labels in the...
متن کاملA 19F NMR study of 2-deoxy-2-fluoro-D-galactose in mice.
The metabolic pathway of 2-deoxy-2-fluoro-D-galactose (FDGal) in mice was studied by 19F NMR. Efficient accumulation of FDGal in liver was demonstrated by NMR, which is consistent with the results of Ishiwata et al. using radioactive 18FDGal. The new discovery is that this fluorinated hexose was converted to 2-deoxy-2-fluoro-D-glucose (FDG) through UDP-FDGal and UDP-FDG apparently by the action...
متن کاملSynthesis, Quality Control and Stability Studies of 2-[18F]Fluoro-2-Deoxy-D-Glucose(18F-FDG) at Different Conditions of Temperature by Physicochemical and Microbiological Assays
The introduction of 2-[18F] fluor-2-deoxy-D-glucose (18FDG) has provided a valuable tool for the study of glucose metabolism in both normal and diseased tissue in conjunction with positron emission tomography (PET). 18FDG is the most important radiopharmaceutical to be used in Nuclear Medicine for studying the brain, heart and tumor. The advancement in synthesis and quality control of 18FDG and...
متن کاملSynthesis, Quality Control and Stability Studies of 2-[18F]Fluoro-2-Deoxy-D-Glucose(18F-FDG) at Different Conditions of Temperature by Physicochemical and Microbiological Assays
The introduction of 2-[18F] fluor-2-deoxy-D-glucose (18FDG) has provided a valuable tool for the study of glucose metabolism in both normal and diseased tissue in conjunction with positron emission tomography (PET). 18FDG is the most important radiopharmaceutical to be used in Nuclear Medicine for studying the brain, heart and tumor. The advancement in synthesis and quality control of 18FDG and...
متن کاملSynthesis of 2’-Deoxy-2’-fluoro-L-arabinofuranosyl Imidazole Derivatives
The last few years have witnessed a revival of interest in analogues of nucleosides following the discoveries that several of such compounds exhibit powerful antiviral effects. Structural modifications of naturally occurring nucleosides often lead to the discovery of new agents displaying biological and chemotherapeutic activity. A greal deal of effort has been directed towards the modification...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Helvetica Chimica Acta
سال: 1997
ISSN: 0018-019X
DOI: 10.1002/hlca.19970800614